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1.
São Paulo med. j ; 116(6): 1879-81, nov.-dez. 1998. ilus
Article in English | LILACS | ID: lil-229429

ABSTRACT

Context: Spinal cord compression due to extramedullary hematopoiesis is a well-described but rare syndrome encountered in several clinical hematologic disorders, including beta-thalassemia. Case Report: We report the case of a patient with intermediate beta-thalassemia and crural paraparesis due to spinal cord compression by a paravertebral extramedullary mass. She was successfully treated with low-dose radiotherapy and transfusions. After splenectomy, she was regularly followed up for over four years without transfusion or recurrence of spinal cord compression. Discussion: Extramedullary hematopoiesis should be investigated in patients with hematologic disorders and spinal cord symptoms. The rapid recognition and treatment with radiotherapy can dramatically alleviate symptoms.


Subject(s)
Humans , Female , Adult , Spinal Cord Compression/radiotherapy , Hematopoiesis, Extramedullary/radiation effects , beta-Thalassemia/complications , Follow-Up Studies
2.
Arq. neuropsiquiatr ; 54(3): 479-83, set. 1996. ilus
Article in Portuguese | LILACS | ID: lil-184781

ABSTRACT

Relatamos o caso de um paciente, de 28 anos, portador de nevo melanocítico gigante congênito(NMGC), com transformaçao em melanoma e metátase no sistema nervoso central (SNC). Descreveremos resumidamente as características patológicas de ambas as lesoes (NMGC e melanoma), a frequência de malignizaçao no NMGC, os órgaos mais frequentemente acometidos pelas metástases do melanoma - dando ênfase ao acometimento do SNC - além dos fatores que podem levar à malignizaçao do NMGC, os exames usados para o diagnóstico das metástases no SNC - ressaltando a importância do líquido cefalorraquiano - e algumas modalidades terapêutica para o melanoma com acometimento do SNC.


Subject(s)
Humans , Male , Adult , Brain Neoplasms/cerebrospinal fluid , Melanoma/cerebrospinal fluid , Neoplasm Metastasis/diagnosis , Skin Neoplasms/congenital , Skin Neoplasms/pathology , Meningeal Neoplasms/cerebrospinal fluid , Nevus, Pigmented/congenital , Nevus, Pigmented/pathology , Melanoma/pathology
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